Help! My Dog Has Mange! (Vet Answered)

ℹ️Ashley asks about their dog, Abby
🗓️Asked on 5 February 2026
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This question has been answered by a vet

Dr. Paola Cuevas
Dr. Paola Cuevas MVZ

Veterinarian & Animal Behaviorist

With nearly two decades in veterinary medicine, Dr. Paola brings hands-on experience across multiple species. A graduate of the University of Guadalajara, she specializes in preventive care, animal welfare, and positive reinforcement training.

The Question

“Dear Dr. Paola,

I have spent $600 on medicines and shampoos to treat my large dog’s mange. Why are none of them working? Her name is Abby. ”  – Ashley

Quick Info about Abby

Sex: Female
Dr. Paola Cuevas
Dr. Paola replied on 5 February 2026

Dear Ashley,

I’m really sorry to hear that Abby is still struggling with mange despite all your efforts. When treatments aren’t working, especially after investing heavily in medications and shampoos, it usually means there’s either a misdiagnosis, an underlying condition interfering with healing, or the treatment protocol isn’t being applied consistently or thoroughly enough.

First, it’s important to confirm the exact type of mange Abby has. Demodectic mange, caused by Demodex mites, is often linked to a weakened immune system and can be particularly stubborn in adult dogs. On the other hand, sarcoptic mange, caused by Sarcoptes scabiei, is intensely itchy and highly contagious. Both require different treatment approaches, and a skin scraping examined under a microscope is essential to identify the mite type and assess the effectiveness of therapy. If this hasn’t been done recently, or if Abby’s condition has changed, it may be time to repeat it.

Secondly, treatment failure can also result from incomplete mite eradication, re-infestation from untreated environments or animals, or secondary infections that haven’t been addressed. Some medicated shampoos and topical treatments can soothe the skin but do little to eliminate mites. Systemic therapies like isoxazolines (e.g., fluralaner and afoxolaner) have been shown to work well on both types of mange in peer-reviewed studies, but they must be given in a full, uninterrupted schedule.
Since these medications require a prescription, you’ll need to consult your veterinarian, who can assess Abby’s overall health, confirm the mite diagnosis, and determine if these or alternative treatments are right for her. It’s essential to use these under veterinary guidance, especially given Abby’s ongoing challenges. If Abby is not responding despite using such products, a detailed re-evaluation is warranted. In some cases, resistant mites or concurrent health issues like hypothyroidism or allergies can interfere with recovery. A full diagnostic workup, ideally guided by a veterinary dermatologist, can reveal what might be missing.

Good luck!

Dr. Paola

Disclaimer: The advice provided here is for informational purposes only and does not constitute a medical diagnosis. Always consult your local vet for emergencies.
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